在隔离的羊心脏中,心房除对心室的冲击的影响
1Department of Pharmacology, SUNY Health Science Center at Syracuse, NY 13210, USA.
Circulation
|May 21, 1998
概括
心房除冲击可以在低电压下激发心室,从而影响激活序列. 在脆弱时期的冲击可能会通过焦点刺激和回入波诱导心室动.
科学领域:
- 心血管电生理学 心血管电生理学
- 心脏节律失常症 心脏节律失常症
背景情况:
- 心房动心脏转变对心室激活模式的影响仍未得到充分研究.
- 这项研究调查了心房除冲击后的心室事件.
研究的目的:
- 为了阐明心房 défibrillation 冲击对心室激活序列的影响.
- 为了确定冲击参数和心室激发/动之间的关系.
主要方法:
- 利用视频成像和心表膜跨膜潜能记录在Langendorff透的绵羊心脏模型中.
- 应用可编程心房除器的双相冲击,并分析了心室脱极化模式.
主要成果:
- 腹痛期间的低电压冲击 (10V) 诱导了心室刺激,延迟时间为~30毫秒.
- 较高的电压 (120V) 将延迟降低到零,导致快速的表心去极化.
- 在脆弱时期 (150-300毫秒后刺激) 的冲击通过焦点刺激和重新进入诱导了心室动.
结论:
- 心房除冲击有效地激发心室,即使在低电压下.
- 心室动可以在脆弱时期被冲击触发,导致复发性心律失常.
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