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Updated: Aug 4, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

G蛋白贝塔玛子单元与效应物的相互作用的分子基础

C E Ford1, N P Skiba, H Bae

  • 1Institute for Neuroscience and Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, IL 60611, USA.

Science (New York, N.Y.)
|June 20, 1998
PubMed
概括

关氨酸核酸结合蛋白 (G蛋白) 通过阿尔法和贝塔亚单元传递信号. 研究人员确定了对效应器调节至关重要的特定Gbeta残留物,揭示了对信号传输至关重要的重叠相互作用领域.

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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