在shaker-2小鼠中,通过BAC转基因中的非传统肌肉素纠正聋

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Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane
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Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Published on: March 16, 2015

F J Probst1, R A Fridell, Y Raphael

  • 1Department of Human Genetics, 4701 MSRB III, University of Michigan, 1500 West Medical Center Drive, Ann Arbor, MI 48109, USA.

Science (New York, N.Y.)
|June 20, 1998
PubMed
概括

与人类耳聋 (DFNB3) 相关的shaker-2小鼠突变是由Myo15基因的缺陷引起的. 这种基因对于听觉毛细胞中适当的actin组织至关重要,防止听力损失.

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.