在HIV阳性和HIV未确定的受试者肺癌中的分子变化的比较
I I Wistuba1, C Behrens, S Milchgrub
1Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas 75235-8593, USA.
JAMA
|May 30, 1998
概括
人类免疫缺陷病毒 (HIV) 相关的肺癌显示显著更高的微卫星变异率,表明基因组不稳定性. 这些分子变化在HIV阳性患者中比零星肺瘤更频繁.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 遗传学 是一个遗传学.
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染与恶性瘤风险增加有关,特别是原发性肺癌.
- 感染艾滋病毒的人群患肺癌的发病率高于普通人群.
研究的目的:
- 为了研究HIV相关的肺瘤中的分子变化.
- 为了将这些变化与艾滋病毒未确定的 (偶发性) 个体的肺癌进行比较.
主要方法:
- 对11名艾滋病毒阳性和35名艾滋病毒未确定的个体的档案组织进行分析.
- 使用PCR和微卫星标记物评估异构性损失 (LOH) 和微卫星变化 (MA).
- 经过HIV和人类乳头瘤病毒 (HPV) 序列检测.
主要成果:
- 在艾滋病毒相关和零星瘤之间,总的LOH频率相似.
- 微卫星变化 (MA) 在与艾滋病毒相关的瘤 (18%) 与零星瘤 (3%) (P<.001) 中高出6倍.
- 91%的艾滋病毒相关瘤至少有一次MA,相比之下,48%的零星瘤 (P=.02).
结论:
- 微卫星变化表明基因组不稳定性,在与艾滋病毒相关的肺癌中明显更频繁.
- 与艾滋病毒相关的肺癌中MAs增加的潜在机制仍然是未知的.
- 增加的MAs可能在许多艾滋病毒相关的恶性瘤的发病过程中发挥关键作用.
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