在大脑中释放益乳素的
1Discovery Research Laboratories I, Pharmaceutical Discovery Research Division, Takeda Chemical Industries Ltd, Tsukuba, Ibaraki, Japan. HinumavShuji@takeda.co.jp
Nature
|June 2, 1998
概括
研究人员发现了一种新型的激素,即释放益乳素的,它特别刺激益乳素的分泌. 这一发现填补了对垂体激素调节的理解的空白,并确定了一种新的G蛋白结合受体连接体.
科学领域:
- 内分泌学 在内分泌学.
- 神经内分泌学神经内分泌学
- 分子内分泌学分子内分泌学
背景情况:
- 脑下垂体激素调节前垂体功能,除了前乳腺激素.
- 益生菌在哺乳动物的繁殖和哺乳中起着至关重要的作用.
- 一种特定的催乳素释放激素尽管很重要,但仍然难以捉摸.
研究的目的:
- 为了确定一种新型的类激素,该激素调节益乳素分泌.
- 描述介导这种潜在激素作用的受体.
- 调查新型下丘脑因子在垂体调节中的作用.
主要方法:
- 隔离编码孤儿受体 (hGR3) 的互补DNA,该受体在人体垂体中特异地表达.
- 检查下丘脑提取物对hGR3.3的内源性联体的选.
- 实验室功能测试使用大鼠前垂体细胞来评估益生素释放活性.
主要成果:
- 从下丘脑中鉴定出一种新型,作为hGR3.3的内源性联体.
- 新发现的与已知的或蛋白质没有任何序列相似之处.
- 这种被证实是大鼠前垂体细胞中强有力的前素释放因子.
结论:
- 这种新被命名为释放益生菌素的,是一种强大的激活益生菌素分泌的刺激剂.
- 这一发现确定了孤儿受体hGR3的特定连接体,hGR3是一种G蛋白结合受体.
- 这些发现有助于我们更好地理解下丘脑-垂体轴调节的作用,特别是对益生菌的控制.
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