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对于复发性心周炎的科尔奇辛治疗. 一个十年的经验
Y Adler1, Y Finkelstein, J Guindo
1Department of Cardiology, Rabin Medical Center, Petah Tiqva, Israel.
Circulation
|June 17, 1998
概括
科尔奇辛在预防复发性心周炎,急性心周炎的常见并发症方面表现有前途. 这种抗炎药物可以作为有效的辅助或初始治疗,特别是在特异性病例.
科学领域:
- 心脏病学 心脏病学
- 内部医学 内部医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 再发性心膜炎影响15-32%的急性心膜炎患者.
- 复发的原因通常是未知的,但可能包括病毒感染或心脏手术后的心脏病.
- 目前的预防策略包括NSAIDs,皮质类固醇,免疫抑制剂和心脏切除术,没有完全确定的最佳方法.
研究的目的:
- 审查菌素在预防复发性心膜炎发作中的有效性和安全性.
- 根据最近的数据,根据最近的数据,评估colchicine作为复发性心膜炎的辅助或初始治疗.
主要方法:
- 审查过去十年累积的新试验数据.
- 分析了一项大型多中心国际研究的结果,该研究涉及51名用素治疗的患者.
- 对患者进行长达10年的随访.
主要成果:
- 科尔奇辛在小型研究中已成功地预防心膜炎复发.
- 一项涉及51名患者的大型国际研究显示,用黄素治疗的结果是积极的.
- 该药物的有效性得到了其在家族地中海热病中经过验证的使用的支持.
结论:
- 科尔奇辛是一种有前途的补充剂,用于常规治疗复发性心膜炎.
- 胆固醇可以被视为初始治疗选择,特别是在异常性心膜炎.
- 证据支持菌素在预防心膜炎复发中的有效性和安全性.
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