税收蛋白与MEKK1结合,刺激IkappaB激酶活性和NF-kappaB激活

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M J Yin1, L B Christerson, Y Yamamoto

  • 1Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75235-8594, USA.

Cell
|June 18, 1998
PubMed
概括

HTLV-I Tax蛋白通过与MEKK1结合来激活NF-kappaB信号,从而增强IKKbeta活动. 这种相互作用促进IkappaB的α降解,导致NF-kappaB的核转位和炎症反应.

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