用于治疗儿童普通感冒的糖酸药片:一项随机对照试验
M L Macknin1, M Piedmonte, C Calendine
1Department of Pediatrics and Adolescent Medicine, Cleveland Clinic Foundation, Ohio 44195, USA.
JAMA
|June 27, 1998
概括
糖酸甘氨酸 (ZGG) 药片在儿童和青少年中没有缩短感冒的持续时间. 这项研究没有发现症状缓解时间的显著差异,而在组中报告的不良反应增加.
科学领域:
- 儿科健康 儿科健康
- 传染性疾病 传染性疾病
- 营养科学 营养科学
背景情况:
- 感冒是一种广泛传播的疾病,导致严重的发病率和经济负担.
- 在生物化学上,被认为是一种潜在的感冒治疗方法.
- 糖酸甘氨酸 (ZGG) 药片在减少成人感冒持续时间方面表现出有效性.
研究的目的:
- 评估ZGG软糖片治疗儿童和青少年常见感冒症状的有效性.
- 评估ZGG对症状缓解时间和儿科群体的不良影响的影响.
主要方法:
- 一个随机的,双面罩,安慰剂对照试验,涉及两个学区的249名学生 (1-12年级).
- 参与者在经历至少两种感冒症状时,接受了ZGG (10毫克) 或安慰剂.
- 每天追踪咳,头痛,声,肌肉疼痛,鼻塞,鼻水排水,喉,喉疼痛和打喷的症状.
主要成果:
- 在ZGG和安慰剂组之间,所有感冒症状消失的时间没有显著差异 (两者的中位数为9天).
- 对于任何个体症状的解决时间,没有观察到显著的差异.
- 与安慰剂组相比,ZGG组报告了更高的不良反应率,包括味道不佳,恶心和口腔/喉不适.
结论:
- 发现ZGG软糖片在治疗儿童和青少年常见感冒症状方面无效.
- 建议进行进一步的研究,包括病毒学测试,以阐明在感冒症状管理中的作用.
- 这项研究强调了儿童群体中ZGG使用的潜在不良影响.
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