与艾滋病相关的恶性疾病的谱
J J Goedert1, T R Coté, P Virgo
1Viral Epidemiology Branch, National Cancer Institute, Rockville, MD, USA. jg8s@nih.gov
Lancet (London, England)
|July 4, 1998
概括
艾滋病患者患有霍奇金病,多发性骨髓瘤,脑癌和半瘤的风险明显增加. 这些发现表明,获得性免疫缺陷综合征 (艾滋病) 与某些癌症之间存在联系,除了卡波西肉瘤和非霍奇金淋巴瘤之外.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 获得性免疫缺陷综合征 (艾滋病) 与某些癌症有关.
- 澄清艾滋病相关癌症的全谱对于患者护理和公共卫生至关重要.
研究的目的:
- 为了确定由艾滋病引起的特定癌症类型.
- 将艾滋病患者的癌症发病率与普通人口进行比较.
主要方法:
- 利用美国和波多黎各的基于人口的癌症和艾滋病登记册.
- 使用概率匹配算法对98,336名艾滋病患者和1,125,098名癌症患者的姓名,出生日期和社会安全号码进行匹配.
- 根据艾滋病后发生率显著增加和艾滋病诊断期间的患病率增加而定义的与艾滋病有关的癌症.
主要成果:
- 在艾滋病患者中,卡波西肉瘤 (310倍) 和非霍奇金淋巴瘤 (113倍) 的确诊率显著增加.
- 鉴定了霍奇金病 (7.6倍),多发性骨髓瘤 (4.5倍),脑癌 (3.5倍) 和半瘤 (2.9倍) 的发生率和患病率显著增加.
- 观察到其他癌症的发病率增加了1.9倍,特定恶性疾病的发病率显著增加.
结论:
- 艾滋病与霍奇金病,多发性骨髓瘤,脑癌和半瘤的风险显著增加有关.
- 控制病毒感染的免疫缺陷可能会导致这些艾滋病相关的恶性疾病的发展.
- 共同的风险因素和查的复杂性要求仔细解释研究结果.
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