过量使用海洛因导致的死亡:头发分析的结果
F Tagliaro1, Z De Battisti, F P Smith
1Institute of Forensic Medicine, University of Verona, Policlinico, Italy.
Lancet (London, England)
|July 8, 1998
概括
由于过量服用而死亡的海洛因成者头发吗啡水平低于活跃使用者,这表明戒断后的耐受性降低增加了过量服用的风险. 这突显了脱毒计划中个人复发的危险.
科学领域:
- 法医毒理学 法医毒理学
- 成 药物 药物 药物 药物
- 药理学 药理学是指药理学的学科.
背景情况:
- 头发吗啡分析在法医毒理学中对于了解海洛因成史至关重要.
- 在已故的海洛因成者身上调查头发吗啡含量可以阐明导致致命过量服用的因素.
研究的目的:
- 在已故的海洛因成者身上测量头发吗啡含量.
- 探索致命的海洛因过量服用和先前的成行为之间的相关性.
- 为了比较死去的成者的吗啡水平与活跃的成者,戒断的成者和未暴露的个人.
主要方法:
- 对头发样本的分析 (大约. 150毫克) 来自37名已故的海洛因成者,37名活跃使用者,37名戒断使用者和20名对照者.
- 使用放射性免疫试验 (RIA) 和高性能液态染色学 (HPLC) 量化了吗啡含量.
主要成果:
- 与活跃使用者 (6.07 ng/mg) 相比,已故成者的平均头发吗啡含量显着较低 (1.15 ng/mg).
- 已故成者的吗啡水平与戒断的前成者 (0.74 ng/mg) 并没有显著不同.
- 没有暴露的个体的吗啡水平低于检测极限.
结论:
- 在已故成者中,较低的头发吗啡水平表明,在戒断期间后,耐受性丧失,增加了过量服用的易感性.
- 医疗保健专业人员应该意识到在接受排毒的患者中复发和过量服用的风险增加.
- 即使偶尔使用海洛因而没有耐受性,也可能构成严重的过量风险.
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