昆虫中的组合化学:一种防御性宏环多氨酸的库
F C Schröder1, J J Farmer, A B Attygalle
1Department of Chemistry, Cornell University, Ithaca, NY 14853, USA. fs31@cornell.edu
Science (New York, N.Y.)
|July 17, 1998
概括
这是北方甲甲虫 (Epilachna borealis) 的甲虫.
科学领域:
- 自然产品化学 自然产品化学
- 有机化学 有机化学
- 昆虫的生物化学 昆虫的生物化学
背景情况:
- 分析了虫甲虫Epilachna borealis的幼防御分泌物.
- 之前的研究还没有发现这种类型的化合物.
研究的目的:
- 描述防御分泌物的化学组成.
- 识别和阐明新型自然产品的结构.
主要方法:
- 对甲虫的防御分泌物的化学分析.
- 使用光谱方法阐明已识别的化合物的结构.
- 对生物合成途径的研究.
主要成果:
- 分泌物主要由多样化的宏环聚氨酸库组成.
- 这些宏环聚氨酸代表了一种新的自然产品家族.
- 这些结构的特点是由由 (2-基乙氨基) 酸形成的大乳酸环.
- 组合组装和自发重新排列有助于结构多样性.
结论:
- 北采用独特的组合策略,产生结构多样化的防御化合物.
- 这一发现扩大了已知的自然产品的范围,并突出了昆虫中的新生物合成机制.
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