胎儿生长障碍和动脉和周围动脉动脉硬化
C N Martyn1, C R Gale, S Jespersen
1MRC Environmental Epidemiology Unit, Southampton General Hospital, UK. c.martyn@mrc.soton.ac.uk
Lancet (London, England)
|July 31, 1998
概括
低出生体重与动脉样硬化增加有关,特别是在动脉中. 胎儿生长障碍可能导致长期的血管变化,增加成人心血管疾病的风险.
科学领域:
- 血管生物学 血管生物学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 流行病学研究表明,低出生体重的成年人患冠心病和中风的风险更高.
- 连接低出生体重与成人心血管疾病的机制尚不清楚.
- 动脉样硬化是心血管疾病发展的关键因素.
研究的目的:
- 为了调查胎儿生长受损,出生时体重低是否会增加动脉样硬化风险.
- 根据可用的出生体重数据,评估70岁左右的个体的动脉和下肢动脉.
主要方法:
- 这项研究包括322名参与者 (在2232名出生于1922-1926年的2232人中) 拥有可用的出生记录.
- 在181名参与者中通过双重超声扫描评估了动脉动脉样硬化.
- 在186名参与者中,使用脚-手臂压力指数 (ABPI) 评估下肢动脉样硬化.
主要成果:
- 最低的出生体重与动脉动脉样硬化的最大患病率和严重程度有关.
- 出生时体重为6.5磅或更少的个体患上动脉狭窄症的风险明显更高 (OR 5.3).
- 在出生体重最低的个体中观察到下肢动脉硬化增加的趋势,但在统计学上不显著 (OR 2.3).
结论:
- 增加动脉动脉生成 (斑块积累) 是一个潜在的机制,将受损的胎儿生长与心血管疾病联系起来.
- 胎儿生长限制可能会导致血管结构和新陈代谢的持久变化.
- 低出生体重是成人动脉样硬化,特别是动脉疾病的重要危险因素.
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