通过超声波直接体内可视化微气泡的血管内破坏及其对组织的局部影响
D M Skyba1, R J Price, A Z Linka
1Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA.
Circulation
|August 26, 1998
概括
超声波在体内破坏微泡,导致微血管破裂和细胞损伤. 这种生物效应显示了向药物输送和瘤破坏的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 超声波技术 超声波技术 超声波技术
- 微血管研究 微血管研究
背景情况:
- 研究超声波诱导的血管内微泡破坏.
- 描述微气泡化所产生的生物效应.
研究的目的:
- 在体内观察和描述超声波诱导的微气泡破坏.
- 为了将超声波能量与由此产生的生物效应相关联.
主要方法:
- 使用静脉内显微镜可视化大鼠脊柱状肌肉.
- 输送超声波能量以诱导微泡的破坏.
主要成果:
- 微气泡的破坏导致了微血管的破裂,主要是毛细血管.
- 邻近的组织显示了不可活性的细胞的产生.
- 在超声波能量和微血管破裂/细胞损伤之间发现了线性相关性 (P<0.001).
结论:
- 超声波可以有效地破坏微泡,诱导局部生物效应.
- 潜在的应用包括向药物输送,血管生成,血管改造和瘤破坏.
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