在有或没有阻塞性睡眠呼吸暂停的肥胖患者中,交感活动
K Narkiewicz1, P J van de Borne, R L Cooley
1Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA.
仅仅肥胖并不会增加肌肉交感神经活动 (MSNA). 然而,肥胖个体的隐性阻塞性睡眠呼吸暂停 (OSA) 显著提高MSNA,这表明OSA是这个人群中同情激活的主要驱动因素.
科学领域:
- 心血管生理学心血管生理学
- 睡眠医学 睡眠医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖与肌肉交感神经活动 (MSNA) 的增加有关.
- 阻塞性睡眠呼吸暂停 (OSA) 也与增加的MSNA有关.
- 肥胖症中OSA的高患病率使得对肥胖症中MSNA的理解变得复杂.
研究的目的:
- 为了确定肥胖本身是否独立于OSA,提高MSNA.
- 研究OSA作为肥胖个体MSNA测量中的潜在混因子的作用.
主要方法:
- 在正常体重和肥胖的人群中测量MSNA.
- 通过多睡眠学,对所有参与者进行了OSA查.
- 在研究之前排除了患有高血压或被诊断为OSA的个体.
主要成果:
- 没有OSA的肥胖受试者与正常体重受试者具有类似的MSNA.
- 一部分肥胖患者有未被诊断的 (隐藏的) OSA.
- 与正常体重和没有OSA的肥胖者相比,患有隐性OSA的肥胖者表现出显著更高的MSNA.
结论:
- 肥胖本身与肌肉交感神经活动增加无关.
- 隐性阻塞性睡眠呼吸暂停是肥胖个体MSNA升高的重要原因之一.
- OSA,不仅仅是肥胖,似乎驱动了对肌肉血管系统的同情性外流增加.
更多相关视频
05:34Auricular Acupuncture as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Sleep Disorders
Published on: August 18, 2023
04:24Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
Published on: September 5, 2025
相关概念视频
Hyperpnea and Hyperventilation
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Sleep Apnea
The condition is more prevalent among...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Heart Failure VI: Adjunct Therapies
