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有证据表明,动脉样硬化病变中的巨细胞含有 ангиотензин II

D D Potter¹, C G Sobey, P K Tompkins

¹Department of Internal Medicine, Cardiovascular Center and Center on Aging, University of Iowa College of Medicine, Iowa City 52242, USA.

|September 4, 1998

概括

ангиотензин II (Ang II) 在和人类的动脉样硬化病变中存在. 这种酸与巨细胞结合,并随着动脉样硬化在子中的回归而减少.

科学领域:

心血管研究研究心血管研究
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

人类单核白细胞具有显著水平的血管素II (AngII).
以前的研究表明Ang II在白细胞中存在.
这项研究研究了动脉样硬化病变中的单细胞/巨细胞内Ang II局部化.

研究的目的:

为了确定Ang II是否存在于动脉样硬化病变内的单细胞/巨细胞中.
为了研究Ang II和巨细胞在动脉样硬化血管中的局部化.
为了评估动脉样硬化回归期间Ang II水平的变化.

主要方法:

胸前大动脉和冠状动脉细分的分析,来自cynomolgus子的正常,动脉样硬化和回归组.
检查通过定向切除术获得的人类冠状动脉动脉样硬化病变.
用特定的抗血清和巨标记物对Ang II进行免疫组合化学染色.

主要成果:

和人类的动脉样硬化病变显示出对Ang II的阳性染色.
在动脉样硬化子血管的亲密介质中与巨细胞结合的Ang II染色.
在动脉样硬化回归后的子病变中,Ang II和巨细胞染色减少.

结论:

确认 ангиотензин II 在灵长类动物模型和人类的动脉样硬化病变中存在.
研究结果表明Ang II在动脉样硬化斑块发育中的作用,特别是与巨细胞相关.
这项研究表明,子在动脉样硬化回归阶段的病变中减少了Ang II.

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