发烧患者的抗炎性细胞因子概况和死亡率
J T van Dissel1, P van Langevelde, R G Westendorp
1Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands.
Lancet (London, England)
|September 12, 1998
概括
对瘤亡因子-α (TNF-α) 的高比例,表明与严重感染患者的致命结局相关的抗炎细胞因子概况. 这一发现表明,在治疗败血症时使用抗炎药物时要谨慎.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 抗炎性细胞因子配置与脑膜炎球菌疾病的致命结果有关.
- 该研究调查了这种特征是否能预测其他感染的不良结果.
研究的目的:
- 确定循环抗炎细胞因子概况和发烧性社区感染患者的不良结果之间的关联.
- 评估介质素-10 (IL-10) 和瘤坏死因子-α (TNF-α) 在预测死亡率中的作用.
主要方法:
- 录取了464名患有发烧的住院患者.
- 血IL-10和TNF-α水平在入院时被测量.
- 收集了临床和微生物学数据,并对患者的结果进行了跟踪.
主要成果:
- 感染导致至少399名患者发烧;33人死亡.
- 与幸存者相比,没有幸存者的IL-10水平显著更高,IL-10与TNF-alpha比率更高.
- 高IL-10度 (RR 2.39) 和高IL-10/TNF-α比率与死亡风险增加有关.
结论:
- 升高的IL-10与TNF-alpha比率,表明抗炎特征,与发烧性社区感染的致命结果有关.
- 这些发现表明,在败血症管理中广泛应用抗炎性细胞因子抑制药物时,应谨慎.
相关概念视频
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