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Published on: December 22, 2016
在阻塞性睡眠呼吸暂停中改变了心血管变异性
K Narkiewicz1, N Montano, C Cogliati
1From the Departments of Internal Medicine and Neurology, Cardiovascular Division, University of Iowa, Iowa City, IA 52242, USA.
阻塞性睡眠呼吸暂停 (OSA) 改变了心血管变异性,即使在没有其他疾病的患者中也是如此. 心率和血压变化的这些变化可能会增加未来心血管事件的风险.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 自主神经系统研究 自主神经系统研究
背景情况:
- 改变心血管变异性是未来心血管事件的关键指标.
- 阻塞性睡眠呼吸暂停 (OSA) 与心血管疾病风险增加有关.
- 这项研究调查了OSA是否会影响心血管变异性,而不依赖于其他疾病.
研究的目的:
- 测试阻塞性睡眠呼吸暂停 (OSA) 与心血管变异性变化相关的假设.
- 为了确定这些变化是否存在,即使没有确诊的心血管疾病.
主要方法:
- 肌肉交感神经活动的光谱分析,RR间隔和血压变化.
- 在中度至重度OSA,轻度OSA和健康对照患者的休息期间进行的测量.
- 参与者是新诊断的,未经治疗的OSA患者,没有其他已知的疾病.
主要成果:
- 与对照组相比,中度至重度OSA患者的RR间隔较短,并增加了同情活动.
- 在中度至重度的OSA患者中,RR间隔变异性降低,具有改变的光谱成分.
- 在中度至重度的OSA患者中,血压变化显著更高,与OSA严重程度相关.
结论:
- 在患有阻塞性睡眠呼吸暂停 (OSA) 的患者中,心血管变异性明显改变.
- 即使没有高血压或心力衰竭,这些异常也存在.
- 这些发现表明,OSA心血管变异的改变可能有助于心血管疾病的发展.
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