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猪的缺血预调:一个分级的现象:它与腺和布拉迪基尼尼的关系

R Schulz¹, H Post, C Vahlhaus

¹Abteilung für Pathophysiologie, Zentrum für Innere Medizin des Universitätsklinikums Essen, Germany.

|September 16, 1998

概括

缺血预调的保护作用是分级的,而不是全部或没有的. 较长的预条件持续时间更多地依赖于腺,而较短的依赖于布拉迪基宁来减少心脏病发作的大小.

科学领域:

心血管生理学心血管生理学
心肌缺血和再生输液损伤的心肌缺血和再生输液损伤
细胞信号在心脏保护中的作用

背景情况:

缺血预先调节 (IPc) 的门概念表明,保护需要最小的刺激.
目前尚不清楚IPc的心脏保护作用是否是二进制的 (全部或没有) 或是剂量依赖的 (分级) 在这个值以上.

研究的目的:

调查是否缺血预制 (IPc) 是一个分级的现象.
阐明布拉迪基宁和腺在不同持续时间的IPc中的作用.

主要方法:

由左前下垂冠状动脉低输液诱导的心肌梗塞的猪模型.
IPc协议涉及低流缺血的不同持续时间 (2,3或10分钟),然后再输血.
通过微透析测量心脏病发作大小 (IS) 和腺素和勃拉迪基宁的间歇度.
药理学阻断布拉迪基宁B2受体 (HOE 140) 和腺 (腺脱氨酶) 以评估介质作用.

主要成果:

经过2分钟的缺血的IPc并没有减少心脏病发作的大小 (IS).
缺血3分钟和10分钟的IPc显著减少了IS (P<0.05).
间歇性腺仅在IPc10分钟时增加,而布拉迪基宁在3分钟和10分钟时增加.
布拉迪基宁的封锁取消了IS的减少3分钟的IPc,但不是10分钟.
结合布拉迪基宁和腺胺阻塞在10分钟的IPc后取消了IS的减少.

结论:

缺血预调表明,在减少心脏病发作大小方面,有分级的剂量反应关系.
在IPc的较短时间内,布拉迪基宁对于心脏保护至关重要.
在IPc的较长时间内,腺素在心脏保护中起着更重要的作用.

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