通过低脂肪乳制品调节异常的结肠上皮细胞增殖和分化:一种随机对照试验
P R Holt1, E O Atillasoy, J Gilman
1Department of Medicine, St Luke's/Roosevelt Hospital Center and Columbia University, New York, NY 10025, USA.
JAMA
|October 3, 1998
概括
通过乳制品增加摄入量可以通过减少细胞增殖和恢复高风险个体的正常细胞分化标志物来帮助预防结肠癌.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 结肠上皮细胞在瘤发育之前表现出改变的生长和分化,作为癌症风险的中间生物标志物.
- 营养和药理干预措施正在通过修改风险粘膜以达到正常特征来探索化疗预防.
研究的目的:
- 调查乳制品中的摄入量增加是否可以使结肠生物标志物正常化.
- 评估食对结肠细胞生长和分化的影响.
主要方法:
- 一项随机,单盲,受控的研究在门诊环境中进行.
- 七十名有结肠腺瘤息肉病史的参与者被随机分配到对照组或更高 (1200毫克/天高低脂肪乳制品) 组,按年龄分层.
- 关键的结果措施包括结肠上皮细胞增殖的变化,素比率 (硫素与素) 和细胞克拉丁AE1/AE2表达.
主要成果:
- 增加摄入量的治疗导致6个月和12个月后结肠上皮细胞增殖活动和增殖区的大小显著减少.
- 在补充的组中观察到,酸性粘素的恢复,正常的细胞蛋白AE1分布,以及核大小朝着正常水平的恢复.
- 与基线相比,对照对象的增殖值没有显著变化.
结论:
- 通过低脂肪乳制品将每日摄入量增加到1200毫克,有效地减少了患结肠直肠瘤风险的个体的结肠上皮细胞增殖.
- 这种饮食干预有助于恢复正常的细胞分化标记物,这表明在结肠癌化学预防中的作用.
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