在囊性纤维化患者中缺少Oxalobacter formigenes:高氧化尿症的危险因素
Lancet (London, England)
|October 6, 1998
概括
缺少肠道细菌Oxalobacter formigenes的囊性纤维化患者患有高氧沙流和结石的风险更高. 这种缺失,通常是由于抗生素,可能会永久改变肠道菌群并增加氧沙酸盐的吸收.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學.
- 胃肠病学 胃肠病学
背景情况:
- 囊性纤维化 (CF) 患者面临高氧化尿,结核病和氧酸盐尿病的风险增加.
- 肠道细菌Oxalobacter formigenes在氧酸盐平衡中发挥着重要作用.
- 丢失O.formigenes与增加的高氧化尿和结石形成有关.
研究的目的:
- 在CF患者中调查O.formigenes缺失和hyperoxaluria之间的相关性.
- 为了确定O.formigenes的殖民化是否在CF患者和健康个体之间有所不同.
主要方法:
- 从43名CF患者和21名健康志愿者 (年龄3-9岁) 的便样本通过培养和DNA分析分析了O.formigenes.
- 收集了24小时的尿样,以测量氧沙酸盐水平和其他与石头有关的因素.
主要成果:
- 与健康志愿者 (71%) 相比,O. formigenes在CF患者 (16%) 的殖民化明显较低.
- 在没有O.formigenes的36名CF患者中,有19名患者 (53%) 呈现高氧,年轻患者的严重程度更高.
- 被O.formigenes殖民的CF患者表现出正常的尿氧酸盐水平.
结论:
- 在CF患者中缺少O.formigenes与氧酸盐吸收增加有关,增加了高氧沙流和相关并发症的风险.
- 长时间使用抗生素和CF相关的胃肠道变化可能导致CF患者O.formigenes的永久脱殖.
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