在人体中,S-尼特罗斯格卢他降低了栓塞率
J Molloy1, J F Martin, P A Baskerville
1Department of Clinical Neuroscience, University College Medical School, London, UK.
Circulation
|October 7, 1998
概括
在接受动脉内关节切除术的患者中,S-尼特罗斯格卢他 (GSNO) 显著降低了脑栓塞. 这种氧化供体对治疗血栓栓塞性疾病和评估新的抗血小板药物有前途.
科学领域:
- 神经科学是一个神经科学.
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 目前的抗血小板药物不足以预防复发性中风和全身栓塞.
- 评估新的抗血小板疗法需要有效的体内人体模型.
- 无症状的脑栓塞信号 (ES),可通过间多普勒超声波检测,是常见的心脏内关节切除术后的信号,提供了一个合适的模型.
研究的目的:
- 评估氧化物供体S-nitrosoglutathione (GSNO) 在降低脑栓塞的疗效.
- 评估心血管内关节切除术后的抗血小板剂测试模型的实用性.
主要方法:
- 接受静脉注射GSNO的12名患者和12名对照患者接受了大脑动脉内关节切除术.
- 间多普勒超声监测ES手术后的ipsilateral中脑动脉.
- 所有患者都接受了阿司匹林和肝素;ES分析是盲目的治疗组.
主要成果:
- 在最初的3小时术后记录中,ES的中位数在GSNO组 (7.5) 与对照组 (38.5) 相比显著较低 (P=0.018).
- 这种ES的减少持续到手术后6小时.
- 尽管同时服用阿司匹林和肝素,GSNO显示出栓塞率明显降低.
结论:
- 血小板特定的氧化捐赠者,如GSNO,具有治疗血栓栓塞性疾病的潜力.
- 带有ES检测的胆管末端切除术后模型对于确定人类新型抗血小板剂的有效性是有价值的.
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