相关实验视频
Updated: Aug 8, 2026
09:58
A Method for Labeling Vasculature in Embryonic Mice
Published on: October 7, 2011
在过度表达angiopoietin-1的小鼠中增加了血管化
C Suri1, J McClain, G Thurston
1Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Science (New York, N.Y.)
|October 17, 1998
概括
在小鼠皮肤中过度表达血管蛋白-1显著增加了血管生长和分支. 这表明,血管蛋白可能是治疗性血管生成的关键,促进新血管的形成.
科学领域:
- 血管生物学 血管生物学
- 分子和细胞生物学分子和细胞生物学
背景情况:
- 血管内皮质素和血管内皮生长因子 (VEGF) 是血管发育的关键调节剂.
- 维EGF对早期血管发育至关重要,而血管蛋白-1对以后的血管改造至关重要.
研究的目的:
- 为了研究血管发育上 angiopoietin-1 的过度表达的影响.
- 在治疗性血管生成中探索血管蛋白的潜力.
主要方法:
- 转基因小鼠模型,在皮肤中向过度表达血管蛋白-1 .
- 对血管形态的分析,包括血管的大小,数量和分支模式.
主要成果:
- 转基因血管蛋白-1的过度表达导致皮肤中的血管变大,变多,分支较大.
- 证明了angiopoietin-1对促进血管生成的显著影响.
结论:
- ангиопоетин-1 在促进血管生长和复杂性方面发挥着至关重要的作用.
- 血管蛋白对治疗性血管生成策略有前途,可能与VEGF结合使用.
相关概念视频
01:10Mechanism of Angiogenesis
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...