核因子-kappaB在患有不稳定的胸痛的人群中被选择性和明显激活
1Division of Cardiology and Cardiovascular Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. Michael.Ritchie@uc.edu
Circulation
|October 27, 1998
概括
核因子-kappaB (NF-kappaB) 的激活在患有不稳定性胸痛的患者中显著升高,这表明其在急性冠状动脉综合征中的作用. 这种激活是特定的,与冠状动脉疾病的严重程度或治疗无关.
科学领域:
- 心脏病学 心脏病学
- 分子生物学分子生物学
- 炎症研究 炎症研究
背景情况:
- 核因子-kappaB (NF-kappaB) 是一种调节炎症反应的转录因子.
- NF-kappaB的激活与急性炎症和潜在的冠状动脉斑块破裂有关.
- 了解NF-kappaB在冠状动脉疾病 (CAD) 中的作用对于治疗急性冠状动脉综合征至关重要.
研究的目的:
- 调查NF-kappaB激活和冠状动脉疾病 (CAD) 活动之间的相关性.
- 为了确定NF-kappaB激活是否与不稳定的心脏病 (美国) 特别相关.
- 探索NF-kappaB在急性冠状动脉综合征的病理生理学的潜在作用.
主要方法:
- 在102名接受心脏导管治疗的患者中,评估了NF-kappaB的激活,使用电机移动转移试验 (EMSAs).
- 分析了患有不稳定性胸痛,稳定性胸痛和其他心脏病的患者的血液样本.
- 通过竞争,超级转移EMSA和脂多糖刺激来确认NF-kappaB激活特异性和功能.
主要成果:
- 在19名患有不稳定性胸痛 (美国) 的患者中,有17名观察到明显的NF-kappaB激活.
- 在没有美国的83名患者中,只有2名患者表现出明显的NF-kappaB激活,尽管许多人患有严重的CAD.
- NF-kappaB激活是特定的,与其他转录因子,CAD严重程度或药物无关.
结论:
- 在不稳定的胸痛中,NF-kappaB 特别且显著地被激活.
- 这种激活似乎在破坏斑块的机制上涉及,导致急性冠状动脉综合征.
- 在急性冠状动脉综合征中,NF-kappaB激活可能作为临床事件前的早期指标.
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