在患者自发心房动期间,心肌收缩率不是恒定的
C I Brookes1, P A White, M Staples
1National Heart and Lung Institute, Imperial College School of Medicine,Royal Brompton and Charing Cross Hospitals, London, UK.
在心房动中,心肌收缩率会随着心脏节拍的变化而变化,与鼻节奏不同. 这种变化是由于力-间隔关系对心脏的影响.
科学领域:
- 心脏病学 心脏病学
- 心脏电生理学 心脏电生理学
- 心脏衰竭研究研究
背景情况:
- 心房动 (AF) 通常显示可变的中风体积和脉冲压力.
- 这种变化往往仅归因于心室填充的改变.
- 这项研究调查了心肌收缩率是否也在AF中波动.
研究的目的:
- 为了测试心肌收缩率在心房动患者中每次节拍变化的假设.
- 为了比较AF患者的末性压力-体积关系与鼻节律中的对照.
主要方法:
- 使用导电导管管连续测量左心室压力和体积.
- 分析了6名AF患者和4名对照患者的末压力-体积关系.
- 评估了强力-间隔关系,包括机械补偿和后外静态增强.
主要成果:
- 鼻节律的对照患者表现出正常的阳性末压力-体积关系.
- AF患者没有显示出一致的积极关系;斜率接近零或负,表明收缩率发生变化.
- 末缩体积和前一个RR间隔 (机械还原) 之间存在显著的负相关性.
- 末性体积和先前的R-R间隔 (后外性增强) 之间存在显著的正相关性.
结论:
- 心肌收缩性在心房动中不是恒定的.
- 收缩率的节拍对节拍变化是由力-间隔关系驱动的.
- 这些发现挑战了传统的观点,即将AF的血液动力学变化仅归因于心室填充.
更多相关视频
10:53Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
Published on: July 3, 2013
08:10Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
相关概念视频
Specialized Characteristics of Cardiac Muscles
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...
Mechanism of Cardiac Arrhythmias
Pathophysiology of Cardiac Performance
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Dysrhythmias III: Characteristics of Dysrhythmias
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
