拉斯通过降低皮肤表达的调节来促进Drosophila的细胞存活
1Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA.
Cell
|November 14, 1998
概括
拉斯激活可以防止果发育过程中的细胞死亡. 这种由Ras/MAPK级联调节的生存途径,降低了亲细胞突变基因头部内置缺陷 (hid) 的下调,促进了细胞生存.
科学领域:
- 发展生物学 发展生物学
- 细胞死亡途径 细胞死亡途径
- 分子信号传输的方法
背景情况:
- 拉斯信号在细胞过程中起着至关重要的作用,包括发育和生存.
- 细胞亡或编程细胞死亡对于正常发育至关重要.
- 德洛索菲拉EGF受体和Raf/MAPK通路是Ras信号传输的关键组成部分.
研究的目的:
- 为了研究Ras信号在抑制Drosophila发育期间的亡中的作用.
- 阐明Ras信号调节细胞死亡的分子机制.
主要方法:
- 在Drosophila melanogaster中进行基因分析.
- 操纵Ras/MAPK通路和细胞死亡调节者的表达 (Reaper和头部内置缺陷).
- 在发育中的眼睛和胚胎中评估亡水平.
主要成果:
- 拉斯激活抑制了Drosophila眼睛在发育中的亡.
- 拉斯/MAPK通路调节由收割机和头部卷积缺陷引起的亡.
- 宫外激活Ras/MAPK抑制了自然的亡并降低了隐藏的亲亡基因的调节.
- 希德的零基因基因模仿了Ras/MAPK的抗芽作用.
结论:
- 通过Raf/MAPK通路传递Ras信号,是Drosophila发育中的细胞亡的关键抑制剂.
- 低调的proapoptotic基因是Ras促进细胞存活的一个关键机制.
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