棕树提取物用于治疗良性前列腺增生:一个系统的审查
1Department of Veterans Affairs Coordinating Center of the Cochrane Collaborative Review Group in Prostatic Diseases and Urologic Malignancies, Minneapolis Veterans Affairs Medical Center, Minn 55417, USA. wilt.timothy@minneapolis.va.gov
JAMA
|November 20, 1998
概括
棕 (Serenoa repens) 提取物有效治疗良性前列腺激增症 (BPH) 症状,改善尿流. 这种植物提取物提供与费纳斯特类似的益处,但副作用较少,使其成为BPH管理的可行选择.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 植物疗法 植物疗法
背景情况:
- 良性前列腺增生 (BPH) 是老年男性常见的疾病,导致下泌尿道症状.
- 棕 (Serenoa repens) 是一种广泛用于治疗BPH症状的草药.
- 关于Serenoa repens对BPH的疗效和安全性的证据需要进行系统的评估.
研究的目的:
- 系统地审查和分析Serenoa repens在症状BPH男性的治疗疗效和安全性.
- 为了比较Serenoa repens与安慰剂和费纳斯特的作用.
主要方法:
- 对18项涉及2939名男性的随机对照试验 (RCT) 的系统综述和元分析.
- 纳入标准:有症状的BPH,Serenoa repens干预,安慰剂或药物控制,治疗持续时间≥30天.
- 数据提取包括研究设计,参与者特征,治疗分配和结果;16项研究是双盲的.
主要成果:
- 与安慰剂相比,Serenoa repens显著改善了泌尿道症状得分,夜尿和尿液流量峰值.
- 在改善尿路症状和流量方面,Serenoa repens的有效性与费纳斯特相当.
- 副作用在Serenoa repens中是轻微的和不常见的,勃起功能障碍的发生率低于费纳斯特.
结论:
- 塞雷诺亚复原体在改善BPH男性泌尿病症状和流量测量方面表现出治疗疗效.
- 与费纳斯特相比,Serenoa repens提供了类似的好处,但具有更好的安全性.
- 需要对标准化制剂进行进一步的研究,以确认长期有效性和预防并发症.
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