治疗慢性抑郁症的塞特拉林维持阶段疗效:一项随机对照试验
M B Keller1, J H Kocsis, M E Thase
1Department of Psychiatry, Butler Hospital, Brown University, Providence, RI 02906, USA.
JAMA
|December 1, 1998
概括
长期的塞特拉林维持治疗显著防止慢性病患者的抑郁症复发. 这种治疗耐受性良好,并且有效预防高风险个体的抑郁发作.
科学领域:
- 精神病学是一个精神病学.
- 临床药理学 临床药理学
- 神经科学是一个神经科学.
背景情况:
- 慢性主要抑郁症具有很高的患病率和残疾.
- 长期治疗对疾病过程和负担的影响仍未得到充分研究.
研究的目的:
- 评估塞特拉林化在预防抑郁症复发方面的疗效.
- 专注于慢性严重抑郁症或"双重抑郁症"的患者.
主要方法:
- 76周的随机,双盲,安慰剂对照试验.
- 161名患有慢性抑郁症的门诊患者接受了塞特拉林或安慰剂维持治疗.
- 主要结局:重大抑郁症复发的时间.
主要成果:
- 与安慰剂相比,塞特拉林显著降低了抑郁症复发率 (6%与23%,P = .002).
- 在接受塞特拉林治疗的患者中,症状复发的患者较少 (26%与50%相比,P = .001).
- 安慰剂组的复发风险是4.07倍的 (P = .005).
结论:
- 塞特拉林维护疗法是有效的,并且耐受良好.
- 在慢性抑郁症患者中预防抑郁症复发方面表现出显著的有效性.
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