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塞特拉林在患有强迫症的儿童和青少年:多中心随机对照试验
J S March1, J Biederman, R Wolkow
1Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. jsmarch@acpub.duke.edu
JAMA
|December 8, 1998
概括
塞特拉林化水是对患有强迫症的儿童和青少年的一种安全有效的治疗方法,与安慰剂相比,显示出显著的症状改善.
科学领域:
- 儿科精神病学 儿科精神病学
- 临床药理学 临床药理学
- 神经科学是一个神经科学.
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 是强迫症 (OCD) 的第一线治疗方法.
- 在儿科患者群体中SSRI疗效的经验证据不如在成年人中那么强大.
- 塞特拉林化是一种常规处方的SSRI.
研究的目的:
- 评估塞特拉林化在被诊断患有强迫症的儿科患者的安全性和有效性.
- 为儿童和青少年患有强迫症提供SSRI使用的经验支持.
主要方法:
- 进行了一项随机,双盲,安慰剂控制的试验.
- 187名患者 (107名儿童,80名青少年) 接受了12周的塞特拉林或安慰剂治疗.
- 使用儿童耶鲁-布朗强迫症强迫性尺度 (CY-BOCS) 和其他评级尺度来衡量有效性.
主要成果:
- 与安慰剂相比,塞特拉林治疗导致CY-BOCS,NIMH GOCS和CGI-I得分的明显改善.
- 早在第3周就观察到改善,并在整个研究期间持续存在.
- 失眠和恶心等不良事件在使用塞特拉林时更频繁,但在生命体征或实验室测试中没有发现显著异常.
结论:
- 塞特拉林化证明了作为儿童强迫症的短期治疗的安全性和有效性.
- 这些发现支持在患有强迫症的儿童和青少年中使用塞特拉林.
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