不同类型的心房缩会为持续的心房动创造基质
1Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. jolgin@iupui.edu
Circulation
|December 8, 1998
概括
在狗中使用的异质交感变色剂创造了持续心房动 (AF) 的条件. 这种针对性神经干扰改变了电生理学特性,促进了AF维护.
科学领域:
- 心血管电生理学 心血管电生理学
- 自主神经系统的自主神经系统
- 心房动病理生理学
背景情况:
- 受到自主内化影响的异质电生理性质对于维持心房动 (AF) 至关重要.
- 自主功能障碍,特别是交感内,在AF的发展和持久性中发挥着作用.
研究的目的:
- 为了调查使用醇的异质交感性皮化是否可以诱导有利于持续AF的状态.
- 探讨针对性交感性缩对心房折射性和AF周期长度的电生理学影响.
主要方法:
- 15只狗接受了心房上心脏烯的应用,而11只狗接受了假手术.
- 术后评估了AF诱导性,有效耐火期 (ERP) 和AF周期长度.
- 用同情性 ([11C]水合乙,HED) 和寄同情性 (5-[11C]甲基维萨米科尔,MOBV) 标记物的正子发射断层扫描 (PET) 成像评估了神经完整性.
主要成果:
- 在15只用醇治疗的狗中,有14只患有持续性AF,相比之下,在假装组中没有任何一只.
- 醇的应用显著缩短了ERP,增加了折射率和AF周期长度的分散.
- PET成像揭示了在应用部位的HED吸收缺陷,表明交感性缩,没有MOBV吸收缺陷.
结论:
- 异质的同情性心房化与醇有效地促进持续的AF.
- 针对性地破坏交感内置改变了心房电生理学,促进了AF的维持.
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