在完全心脏脱差后的阴道心肺反射
1Department of Internal Medicine (Cardiology), Medical College of Virginia/Virginia Commonwealth University and Hunter Holmes McGuire Department of Veterans Affairs Medical Center, Richmond, VA, USA. minisi.anthony_j.@richmond.va.gov
Circulation
|December 8, 1998
概括
心脏,而不是肺,主要控制性心肺反射. 这种反射调节交感神经活动,以应对血液体积和血压的变化.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统的调节规则
背景情况:
- 关于性心肺反射 afferent输入的起源存在相互矛盾的数据.
- 腹腔,心房和肺部的受体是潜在的来源.
研究的目的:
- 为了确定心脏受体是否是性心肺反射输入的主要来源.
- 为了评估心脏脱差对同情外流的反射控制的影响.
主要方法:
- 在麻醉过的狗身上进行了实验,这些狗有阴道动脉缩.
- 用心周内利多卡因中断了心脏虚静脉的 afferents.
- 在分离前和后的血液体积膨胀期间测量交感神经活动 (RSNA).
主要成果:
- 心脏脱差显著减弱了RSNA对血液体积膨胀的反应.
- 对冠心内尼古丁和左心房膨胀的反应被废除了,证实了心脏 afferent 中断.
- 肺膨胀反应没有受到影响,这表明肺 afferents 完好无损.
结论:
- 心脏是性心肺反射的关联输入的主要来源.
- 这种反射对于控制胸部血量和血压变化期间的交感外流至关重要.
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