有机暴露和乳腺癌的风险
A P Høyer1, P Grandjean, T Jørgensen
1Copenhagen Center for Prospective Population Studies, Denmark.
Lancet (London, England)
|December 16, 1998
概括
暴露于有机化合物迪尔德林与乳腺癌风险增加有关. 这项研究表明,环境中的异性雌激素可能会导致妇女患乳腺癌.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 有机化合物表现出较弱的雌激素效应.
- 这些化合物被怀疑会增加乳腺癌风险.
- 需要对与有机化合物相关的乳腺癌风险进行前性评估.
研究的目的:
- 研究血清中有机化合物度与乳腺癌风险之间的关联.
- 为了评估特定的有机和乳腺癌发病率之间的剂量反应关系.
主要方法:
- 1976年,哥本哈根城市心脏研究中从7712名妇女收集了血清样本.
- 在17年的随访中,发现了268例侵袭性乳腺癌.
- 匹配的病例对照分析包括240名乳腺癌患者和477名对照.
主要成果:
- 迪尔德林显示了与剂量相关的乳腺癌风险显著增加 (OR2.05,p=0.01).
- 贝塔-赫萨克环环素显示出非显著的风险增加趋势 (p=0.24).
- 对于p,p'-dichlorodiphenyltrichloroethane或多化双,没有发现显著的关联.
结论:
- 这些发现支持了将异性雌激素暴露与乳腺癌风险增加联系在一起的假设.
- 迪尔德林暴露是乳腺癌的重要危险因素.
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