为了逆转冠状动脉心脏病,强化生活方式的改变
D Ornish1, L W Scherwitz, J H Billings
1Department of Medicine, California Pacific Medical Center, San Francisco, USA. DeanOrnish@aol.com
JAMA
|December 24, 1998
概括
强化生活方式的改变在五年内显著减缓了冠状动脉样硬化,导致心脏事件较常规护理少. 患者维持了这些心脏健康的习惯,证明了长期的可行性和益处.
科学领域:
- 心血管医学 心血管医学
- 预防性心脏病学 预防性心脏病学
- 生活方式 医学 医疗
背景情况:
- 生活方式心脏试验表明,强化生活方式的改变可以在一年内逆转冠状动脉样硬化.
- 维持这些变化长期以前是不确定的.
研究的目的:
- 评估维持五年强化生活方式改变的可行性.
- 为了评估这些变化对冠状动脉心脏病进展的影响,没有降脂药物.
主要方法:
- 一项随机对照试验,涉及48名冠心病患者.
- 一组接受了强烈的生活方式改变 (饮食,运动,压力管理,戒烟,支持) 五年.
- 对照组接受了通常的护理;用于随访的定量冠状动脉造影.
主要成果:
- 集中生活方式组的患者保持了变化,在五年后冠状动脉狭窄的7.9%的相对改善.
- 对照组的狭窄症相对恶化为27.7% (P=.001).
- 强化治疗组在5年内心脏事件显著减少 (25对45).
结论:
- 强烈的生活方式干预促进冠状动脉样硬化的持续回归.
- 这些生活方式的改变是可行的五年和减少心脏事件.
- 冠状动脉样硬化的进展被停止和逆转,与通常护理组不同.
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