通过NKT细胞介导的CD1d受限免疫球蛋白G形成GPI定抗原
L Schofield1, M J McConville, D Hansen
1Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia. schofield@wehi.edu.au
概括
传统的T细胞反应受到MHC的限制,但对某些抗原的免疫球蛋白G (IgG) 抗体的产生可以通过涉及自然杀手T (NKT) 细胞的CD1d受限制途径绕过这一过程.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 病原体研究 病原体研究
背景情况:
- 免疫球蛋白G (IgG) 抗体的产生通常依赖于CD4+辅助T细胞对主要基因相容性复合体 (MHC) 受限的识别.
- 葡萄糖酸氨醇 (GPI) 定蛋白质对抗体反应提出了独特的抗原挑战.
研究的目的:
- 研究CD1d受限通路在调节IgG对GPI定抗原的反应中的作用.
- 探索抗体生产的替代机制,独立于传统的MHC限制.
主要方法:
- 对参与IgG反应的T细胞识别途径的分析.
- 对CD1d受限抗原呈现的研究.
- 评估抗体产生的反应,以GPI-定抗原从等离子杆菌和Trypanosoma.
主要成果:
- 通过CD4+自然杀手细胞抗原1.1 (NK1.1)+T细胞对GPI部分的CD1d受限识别调节了IgG反应.
- 这一途径涉及依赖于甲状腺的,产生互白素-4的T细胞.
- CD1-NKT细胞通路被证明可以调节IgG对Plasmodium和Trypanosoma表面抗原的反应.
结论:
- 一个受 CD1d 限制的,NKT 细胞依赖的通路促进了快速的,不受 MHC 限制的 IgG 抗体反应.
- 这种机制可能对于对抗呈现GPI定抗原的病原体至关重要.
- 这一途径代表了针对某些病原体的适应性免疫的重要替代途径.
相关概念视频
IP3/DAG Signaling Pathway
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and produces two-second...
Immunoglobulin-like Cell Adhesion Molecules
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...


