概括
没有脏的患者或曾经进行切除术的患者面临严重败血症的高风险,通常是由肺炎球菌引起的. 这些感染很难用抗生素治疗.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 脊柱患者和脊柱切除术后的患者对严重感染非常敏感.
- 在这些人群中,压倒性的败血症和传播的血管内凝血病是显著的风险.
- 常见的病原体包括肺炎链球菌 (pneumococcus).
研究的目的:
- 为了突出肺炎球菌败血症的风险增加在阿斯普莱尼克患者.
- 为了强调使用传统抗生素治疗治疗这些感染的挑战.
主要方法:
- 对临床数据和有关阿斯普莱尼病患者感染的文献的审查.
- 分析常见的致病原体和治疗结果.
主要成果:
- 肺炎球菌被确定为asplenic患者中最常见的病原体.
- 这些受试者的感染对标准抗生素治疗反应不佳.
结论:
- 阿斯普莱尼状况显著增加了严重,可能致命的肺炎球菌感染的风险.
- 目前的抗生素疗法可能不足以治疗这些脆弱患者的败血症.
- 对替代性或辅助性治疗策略的进一步研究是有必要的.
相关概念视频
01:40Cell-mediated Immune Responses
Overview
01:36Humoral Immune Responses
Overview
01:26Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
01:22Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
01:25Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...