概括
脑脊液 (CSF) 中的青素水平在神经患者中被测量. 静脉注射的青素G达到可检测的脑液水平,而肌内素青素G很少做到,这表明潜在的治疗挑战.
科学领域:
- 传染性疾病 传染性疾病
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 尽管接受了标准的青素治疗,神经仍然可以持续存在.
- 脑脊液 (CSF) 分析对于诊断和监测神经病至关重要.
- 青素治疗方案是梅毒的推治疗方案.
研究的目的:
- 为了评估神经病患者的脑液中的青素度.
- 为了比较通过静脉注射的青素G与肌肉内素青素G达到的CSF青素水平.
- 评估青素透到中枢神经系统的适度,以治疗神经.
主要方法:
- 这项研究包括15名确诊患有神经和CSF多细胞瘤的患者.
- 两名患者接受了静脉注射的青素G (5-10万单位/天) 四周.
- 13名患者接受了肌肉内素青素G (3.6万单位/周) 四周.
- 在治疗期间或治疗后通过腰椎穿刺采集了CSF样本,以测定青素水平.
主要成果:
- 两名静脉注射青素G的患者中的一个在CSF中有0.3mcg/ml青素;另一个有2.4mcg/ml.
- 在13名患者中,12名患者在肌肉内注射奔氨酸青素G时,有无法检测到的CSF青素水平.
- 一名接受肌内素青素G的患者在CSF中有0.1μg/ml的青素.
结论:
- 静脉注射的青素G在神经患者中,与肌肉内素青素G相比,在脑液中透得更好.
- 低或不可检测的CSF青素水平与标准的素青素G疗法可能解释治疗失败在神经.
- 替代或增强的青素剂量策略可能是有效的神经治疗的必要条件.
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