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Updated: Jul 24, 2026

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Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
用肺炎球菌多糖体疫苗重新接种疫苗的安全性
L A Jackson1, P Benson, V P Sneller
1Immunization Studies Program, Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA, USA. lajack@u.washington.edu
JAMA
|January 26, 1999
概括
在第一剂接种后至少5年,成年人用肺炎球菌多糖体疫苗 (PPV) 重复接种,会增加局部注射部反应的风险. 然而,这些反应是自我限制的,并且不违反推的再接种疫苗.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 在成年人中,用肺炎球菌多糖体疫苗 (PPV) 重复接种可能会导致注射部位局部反应增加.
- 需要进一步定义PPV再接种疫苗的安全性概况,特别是在初次接种疫苗后5年或更长时间的老年人和慢性病患者中.
研究的目的:
- 评估与初级疫苗接种相比,至少在初始疫苗接种后5年的PPV再接种是否与不良事件的频率或严重性增加有关.
主要方法:
- 在1996年4月至1997年8月期间,进行了一项比较干预研究.
- 参与者包括901名从未接种过PPV的50-74岁的个人和513名至少在5年前接种过疫苗的人.
- 该研究比较了第一次接种疫苗的人和接受再接种疫苗的人之间的局部注射部反应和疫苗前抗体水平.
主要成果:
- 再接种疫苗的个体显著更有可能经历局部注射部反应 (11%对3%,RR 3.3).
- 这些反应通常在3天内消失,在免疫能力强,非慢性病重接种者中最为明显 (15%对3%,RR 4.9).
- 疫苗接种前的抗体度与局部反应的风险相关.
结论:
- 自限局部注射部位反应在PPV再接种疫苗后比初级疫苗接种更为常见.
- 这些反应的风险增加并不妨碍对建议人群的PPV再接种疫苗.
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