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瘤基因和Polycomb组基因bmi-1通过ink4a位点调节细胞增殖和衰老

J J Jacobs1, K Kieboom, S Marino

  • 1Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam.

Nature
|January 29, 1999
PubMed
概括

bmi-1基因是Polycomb组蛋白质,它调节细胞循环的进展和衰老. 它的缺失导致缺陷,而其过度表达导致淋巴瘤和癌症,突出其在瘤抑制中的作用.

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