当前和远程血压和认知能力下降
R J Glynn1, L A Beckett, L E Hebert
1Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02215, USA. rglynn@rics.bwh.harvard.edu
JAMA
|February 10, 1999
概括
中年人的血压并不能线性预测老年人的认知能力下降. 然而,存在着复杂的关系,高静脉压显示出认知测试的错误率增加.
科学领域:
- 老年学是指老年学的学科.
- 心血管健康 心血管健康
- 神经科学是一个神经科学.
背景情况:
- 以前的研究表明,中年血压与以后的认知能力下降之间存在潜在联系.
- 了解这种关系对于开发针对老年人群认知障碍的预防策略至关重要.
研究的目的:
- 为了前性地研究血压 (BP) 与认知功能水平以及老年人的变化之间的关联.
- 为了澄清心血管健康和认知衰老之间的复杂相互作用.
主要方法:
- 一项纵向,以人口为基础的研究,利用老年人流行病学研究 (EPESE) 和高血压检测和跟踪计划 (HDFP) 确立人口的东波士顿组成部分的数据.
- 认知功能被评估使用短便携式精神状态问卷和东波士顿记忆测试超过6年.
- 血压在基线和基线评估前9年被测量.
主要成果:
- 血压与认知功能或随时间变化之间没有强烈的线性关联.
- 在基线前9年心压升高 (>或=160毫米柱) 与精神状态问卷错误率增加14%有关.
- 与参考组相比,静脉压和静脉压表现出与认知错误的U形关联,表明较低和较高血压水平的错误增加.
结论:
- 研究结果不支持血压与老年人认知能力下降之间的简单线性关系.
- 结果表明,血压与认知功能之间的联系比以前理解的要复杂得多.
- 需要进一步的研究,以充分阐明BP与衰老中的认知关系背后的复杂机制.
相关概念视频
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Physiological Factors:
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Preparation:
Preparation:
