在成年哺乳动物中枢神经系统中识别神经干细胞
C B Johansson1, S Momma, D L Clarke
1Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Cell
|February 16, 1999
概括
成年哺乳动物大脑中的垂体细胞作为神经干细胞,为嗅球产生新的神经元. 在脊髓损伤后,这些细胞也会为痕组织形成星球细胞.
科学领域:
- 神经科学是一个神经科学.
- 干细胞生物学 干细胞生物学
- 再生医学是一种再生医学.
背景情况:
- 成年哺乳动物的中枢神经系统 (CNS) 呈现着持续的神经发生.
- 负责这种神经发生的多能干细胞的身份仍然难以捉摸.
- 了解神经干细胞的起源对于中枢神经系统的修复和再生至关重要.
研究的目的:
- 为了识别成年哺乳动物中枢神经系统中难以捉摸的神经干细胞.
- 研究表皮细胞在神经发生和中枢神经系统损伤反应中的作用.
主要方法:
- 使用了血统追踪和细胞增殖试验.
- 对模拟脊髓损伤的反应中检查了表皮细胞的行为.
- 追踪了表皮细胞衍生的后代的命运和分化.
主要成果:
- 提出了证据表明,表皮细胞作为神经干细胞起作用.
- 证明,表皮细胞产生神经元迁移到嗅球.
- 在中枢神经系统受伤后表现出尾细胞增殖,产生分化为星球细胞的细胞,并有助于质痕形成.
结论:
- 在特定的成年哺乳动物中枢神经系统区域中,被证实尾细胞是主要的神经干细胞.
- 在中枢神经系统损伤反应中确定了尾细胞的新型作用,有助于神经发生和反应性星病.
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