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Plasma fluoride and enamel fluorosis.

B Angmar-Månsson, Y Ericsson, O Ekberg

Calcified Tissue Research

|November 24, 1976

Summary

Temporary high fluoride (F) levels in blood plasma, not sustained high levels, are linked to enamel fluorosis. Peak plasma F concentrations around 10 muM are critical for blocking tooth enamel formation.

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Area of Science:

Biochemistry
Toxicology
Dental Research

Background:

Fluoride (F) effects on bones and teeth are linked to tissue fluid concentrations, mirrored by blood plasma F.
Plasma F levels are influenced by dietary F intake and skeletal F storage.

Purpose of the Study:

To investigate the relationship between plasma F levels and enamel fluorosis in rats.
To determine the critical plasma F concentrations associated with impaired enamel formation.

Main Methods:

Determined fasting and post-ingestion/post-injection plasma F levels in rats.
Utilized varying dietary F doses to induce different severities of enamel fluorosis.

Main Results:

Temporary peak plasma F values, rather than elevated fasting levels, correlate with enamel fluorosis.
Peak plasma F concentrations approaching 10 muM appear necessary to inhibit ameloblast function and block enamel formation.

Conclusions:

Transient elevations in plasma fluoride are key determinants of enamel fluorosis.
Plasma F level monitoring may have diagnostic and prognostic value for fluoride toxicity assessment.

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