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Trifluridine in resistant human herpetic keratitis
Archives of Ophthalmology (Chicago, Ill. : 1960)
|October 1, 1978
Summary
Trifluridine eye drops effectively treated active dendritic herpetic keratitis unresponsive to other antivirals. Most patients experienced rapid healing of dendritic ulcers with good drug tolerance.
Area of Science:
- Ophthalmology
- Virology
- Pharmacology
Background:
- Dendritic herpetic keratitis is a viral infection of the cornea caused by the herpes simplex virus.
- Herpetic keratitis can lead to vision loss if not treated effectively.
- Existing antiviral therapies like idoxuridine and vidarabine may be ineffective in some cases.
Observation:
- This study evaluated trifluridine, a nucleoside analog, as a topical treatment for herpetic keratitis.
- Patients included had active dendritic ulcers that had not responded to prior antiviral therapies.
Findings:
- Topical 1% trifluridine solution achieved healing of dendritic ulcers in an average of 6.1 days.
- The treatment was generally well-tolerated by the patients.
Implications:
- Trifluridine offers a viable therapeutic option for managing difficult-to-treat herpetic keratitis.
- Early identification and treatment of herpetic keratitis are crucial to prevent vision loss.