Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Testing for selective neutrality of electrophoretically detectable protein polymorphisms.

B S Weir

    Genetics
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Global diversity analysis of plant-associated <i>Pseudopithomyces</i> fungi reveals a new species producing the toxin associated with facial eczema in livestock: <i>Pseudopithomyces toxicarius sp. nov</i>.

    Studies in mycology·2026
    Same author

    <i>Fusarium</i>: more than a node or a foot-shaped basal cell.

    Studies in mycology·2021
    Same author

    Phylogenetic relationships of eight new <i>Dacrymycetes</i> collected from New Zealand.

    Persoonia·2017
    Same author

    Fungal Planet description sheets: 558-624.

    Persoonia·2017
    Same author

    ESTIMATION OF GENE FLOW FROM F-STATISTICS.

    Evolution; international journal of organic evolution·2017
    Same author

    MAINTENANCE OF MALES AND FEMALES IN HERMAPHRODITE POPULATIONS AND THE EVOLUTION OF DIOECY.

    Evolution; international journal of organic evolution·2017
    Same journal

    Coexistence of piRNA and KZFP defense systems: Evolutionary dynamics of layered defense against transposable elements.

    Genetics·2026
    Same journal

    Creation and manipulation of bipartite expression transgenes in C. elegans using phiC31 recombinase.

    Genetics·2026
    Same journal

    Inherited long telomeres induce a genome-wide transcriptional response in budding yeast.

    Genetics·2026
    Same journal

    Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

    Genetics·2026
    Same journal

    Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

    Genetics·2026
    Same journal

    Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

    Genetics·2026
    See all related articles

    This study introduces a new statistical test for gene-frequency data, assessing protein polymorphisms against the stepwise mutation model. The test revealed significant departures from neutral predictions in Drosophila populations, suggesting selection against extreme electrophoretic mobilities.

    Area of Science:

    • Population Genetics
    • Molecular Evolution
    • Biostatistics

    Background:

    • Assessing gene-frequency data for protein polymorphisms in natural populations is complex.
    • Existing methods face challenges in accurately modeling mutation and selection dynamics.

    Purpose of the Study:

    • To develop and validate a statistical test for gene-frequency data.
    • To evaluate protein polymorphisms against the stepwise mutation model in finite populations without selection.
    • To identify deviations from neutral theory predictions.

    Main Methods:

    • Formulated a chi-square minimization approach to estimate stepwise mutation model parameters.
    • Tested remaining deviations under the null hypothesis of neutrality.
    • Applied the test to allozymic locus data from Drosophila willistoni populations.

    Related Experiment Videos

    Main Results:

    • The developed procedure demonstrated conservative properties in simulation data.
    • Approximately 25% of polymorphic loci in Drosophila populations significantly deviated from neutral theory predictions across all populations.
    • An additional 25% showed significant departures in some populations, while the rest fit the charge state model.

    Conclusions:

    • A significant portion of observed protein polymorphisms do not align with neutral evolution predictions.
    • Selection against alleles with extreme electrophoretic mobilities appears to be a predominant evolutionary force.
    • The developed statistical test offers valuable insights into population genetics but has limitations.