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Related Experiment Videos

Dynamic kinetic resolution.

M T Gihani1, J M Williams

  • 1Department of Chemistry, University of Bath, Claverton, Down Bath BA2 7AYUK.

Current Opinion in Chemical Biology
|February 18, 1999
PubMed
Summary
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Transition-metal-enzyme systems enable tandem in situ racemisation and resolutions, advancing dynamic kinetic resolutions. This proactive approach, using enzymes like mandelate racemase, offers new possibilities for multienzyme resolutions.

Area of Science:

  • Biocatalysis and organic synthesis.
  • Enzyme engineering and application.

Background:

  • Dynamic kinetic resolution (DKR) traditionally relies on substrate lability for racemisation.
  • A more proactive approach to racemisation is needed to broaden DKR applications.

Purpose of the Study:

  • To explore the use of transition-metal-enzyme combinations for tandem in situ racemisation and resolution.
  • To highlight the potential of specific racemising enzymes in advancing DKR methodologies.

Main Methods:

  • Employing transition-metal catalysts in conjunction with enzymes.
  • Utilizing in situ racemisation techniques.
  • Investigating the application of specific racemising enzymes, such as mandelate racemase.

Main Results:

Related Experiment Videos

  • The combination of transition metals and enzymes successfully achieved tandem in situ racemisation and resolutions.
  • This methodology expands the scope and efficiency of dynamic kinetic resolutions.
  • Demonstrated a shift from fortuitous racemisation to a more controlled, enzyme-driven process.

Conclusions:

  • Transition-metal-enzyme systems offer a powerful strategy for DKR.
  • The development of specific racemising enzymes is key for future advancements in multienzyme DKR.
  • This work paves the way for more versatile and efficient chiral syntheses.