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Dynamic kinetic resolution
1Department of Chemistry, University of Bath, Claverton, Down Bath BA2 7AYUK.
Current Opinion in Chemical Biology
|February 18, 1999
Abstract:
The use of transition-metal-enzyme combinations to effect tandem in situ racemisation and resolutions has extended the scope of dynamic kinetic resolutions. This methodology has signalled a more proactive stance to the racemisation process, which has traditionally relied on more fortuitous approaches, namely the exploitation of labile substrates. The development and application of specific racemising enzymes such as mandelate racemase offers potential for future multienzyme dynamic kinetic resolutions.