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Manipulation of the C(22)-C(27) region of rapamycin: stability issues and biological implications
F C Nelson1, S J Stachel, C P Eng
1Wyeth-Ayerst Research, Pearl River, NY 10965, USA.
Bioorganic & Medicinal Chemistry Letters
|February 18, 1999
Abstract:
A novel series of rapamycin derivatives with modifications in the C(22)-C(27) region has been prepared. These compounds are evaluated for their ability to prevent ring fragmentation while still retaining immunosuppressive capabilities.