Related Experiment Video
Updated: Jul 28, 2026

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
Published on: July 10, 2018
Experimental assessment of the influence of atmospheric pollutants on respiratory disease
1US Environmental Protection Agency, National Health and Environmental Effects Laboratory, RTP, NC 27711, USA.
Abstract:
Asthma is a chronic respiratory disease characterized by inflammation, episodes of usually reversible airways obstruction, and bronchial hyperresponsiveness. The disease has significant health, societal and economic consequences. Experimental assessment methods, including controlled human exposure studies, human and animal dosimetry, as well as animal and in vitro toxicology, can shed light on how air pollutants may cause and/or worsen asthma. A brief summary background on selected classes of air pollutants is provided and selected experimental studies that exemplify novel approaches or suggest new hypotheses are highlighted. Possible directions for future research about the effects of particles, pesticides, ambient air toxicants, and pollutant mixtures on asthma, are also outlined.
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