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Mechanisms of leukocyte-mediated tissue injury induced by interleukin-2

A B Lentsch1, F N Miller, M J Edwards

  • 1University of Louisville, Department of Surgery, J.G. Brown Cancer Center, Kentucky 40202, USA. ablent01@ulkyvm.louisville.edu

Cancer Immunology, Immunotherapy : CII
|February 18, 1999
PubMed

In this review we discuss the effects of interleukin-2 (IL-2) therapy on trafficking of leukocytes and platelets to normal organs. The use of animal models has allowed the elucidation of events leading to damage and/or dysfunction of normal tissues after IL-2 administration. These studies have shown that acute toxicity induced by IL-2 is mediated primarily by neutrophils. Chronic toxicity results from the adhesion and transmigration of activated lymphocytes into normal organs. Platelet-derived microvascular thrombosis also contributes to the vascular toxicity of IL-2. A better understanding of these mechanisms may lead to the development of interventions that will significantly improve the therapeutic efficacy of IL-2.

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