Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vestibulo-ocular pathways modulate extraocular muscle myosin expression patterns.

J K Brueckner1, L P Ashby, J R Prichard

  • 1Department of Anatomy and Neurobiology, University of Kentucky, Chandler Medical Center, 800 Rose Street, Lexington, KY 40536-0084, USA.

Cell and Tissue Research
|February 18, 1999
PubMed
Summary

Vestibular input shapes extraocular muscle (EOM) development. Disrupting the vestibulo-ocular reflex (VOR) in juvenile rats altered EOM myosin expression, but not in adults, indicating a critical developmental period.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing South African medical interns' experience and confidence in managing obstetric emergencies.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
Same author

Lengthening extraocular muscle with autologous muscle transplants.

Strabismus·2011
Same author

Developmental adaptations in the extraocular muscles of Macaca nemestrina may reflect a predisposition to strabismus.

Strabismus·2011
Same author

Adherence to TB preventive therapy for HIV-positive patients in rural South Africa: implications for antiretroviral delivery in resource-poor settings?

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2005
Same author

Fos immunoreactivity in rat subcortical visual shell in response to illuminance changes.

Neuroscience·2002
Same author

Missed opportunities? Coercion or commitment: policies of prevention.

Annals of the New York Academy of Sciences·2002

Area of Science:

  • Neuroscience
  • Muscle Physiology
  • Developmental Biology

Background:

  • Extraocular muscle (EOM) phenotype is influenced by genetic and epigenetic factors, but these are not well understood.
  • The vestibulo-ocular reflex (VOR) stabilizes eye position and is crucial for visual system function.
  • Vestibular cues may play a role in EOM maturation.

Purpose of the Study:

  • To investigate the role of vestibular input in shaping EOM maturation.
  • To assess how altering the VOR affects EOM development and myosin expression.

Main Methods:

  • Used the ototoxic compound 3',3'-iminodipropionitrile (IDPN) to eliminate VOR receptor hair cells in juvenile and adult rats.
  • Analyzed EOM myosin heavy chain (MyHC) expression via mRNA levels and fiber type analysis after a 2-week survival period.

Related Experiment Videos

Main Results:

  • IDPN administration in juvenile rats increased developmental and fast MyHC isoforms and decreased EOM-specific MyHC mRNA.
  • IDPN treatment in adult rats only affected developmental MyHC isoforms, with no change in EOM-specific MyHC mRNA.
  • These findings suggest VOR modulates EOM-specific MyHC expression during development.

Conclusions:

  • The VOR plays a significant role in modulating EOM-specific MyHC expression during development.
  • There appears to be a critical developmental window where vestibular activity alterations have lasting effects on EOMs.
  • Adult EOMs show resilience to changes in vestibular input compared to developing muscles.