[Functional mechanisms of intravenous immunoglobulins]

Polyclonal immunoglobulins for intravenous use are increasingly used in clinical practice. The mechanisms involved in the treatment of patients with immunodeficiency diseases are not yet clear. In this article we review the most important of these mechanisms and we illustrate the use of immunoglobulins in different diseases. We discuss the interactions with the Fc-receptors, the interactions with the complement system, the influence on superantigens, idiotype-anti-idiotype interactions and the influence on B and T cell receptors. A better understanding of these mechanisms can lead to a better use of these expensive preparations.