Related Experiment Video
Updated: Aug 13, 2026

11:54
Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
A rare case of hereditary multiple impacted normal and supernumerary teeth
V Babu1, K S Nagesh, N R Diwakar
1Department of Pedodontia, Rashtreeya Vidyalaya Dental College.
The Journal of Clinical Pediatric Dentistry
|February 19, 1999
Summary
A young girl had retained baby teeth and impacted extra teeth, a condition also seen in her mother. This case highlights the importance of thorough diagnosis and management for dental anomalies.
Area of Science:
- Dentistry
- Oral and Maxillofacial Surgery
- Pediatric Dentistry
Background:
- Primary tooth retention and supernumerary teeth are common dental anomalies.
- Impacted teeth can lead to various complications, including malocclusion and cysts.
Observation:
- An eight-year-old girl presented with retained primary incisors and multiple impacted permanent and supernumerary teeth.
- Radiographic and histopathological examinations confirmed deficient resorption of primary teeth and impacted supernumerary teeth.
- A family history revealed similar dental anomalies in the mother.
Findings:
- The case presented a complex scenario of retained primary teeth, impacted succedaneous teeth, and impacted supernumerary teeth.
- The genetic predisposition suggested by the family history is a significant factor in the etiology.
- Differential diagnosis and management strategies are crucial for such complex cases.
Implications:
- Early diagnosis and intervention are essential for managing dental anomalies.
- Understanding the genetic component can aid in risk assessment and preventive strategies.
- This case underscores the need for comprehensive dental evaluations in pediatric patients with a family history of dental anomalies.
Related Concept Videos
Pleiotropy
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Nondisjunction
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Nondisjunction
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
Teeth
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Tooth Anatomy
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

