Related Experiment Video

Updated: Sep 16, 2026

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
09:58

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

[Two cases of recurrent bacterial meningitis following traumatic cerebrospinal fluid rinorrhea]

S Ikeda1, T Watanabe, M Sato

  • 1Department of Pediatrics, Niigata City General Hospital.

No to Hattatsu = Brain and Development
|February 20, 1999
PubMed

Insights

Recurrent bacterial meningitis can occur after traumatic cerebrospinal fluid (CSF) leaks. Surgical repair and 3-D CT scans are crucial for diagnosing and treating these CSF fistulas.

Area of Science:

  • Neurology
  • Neurosurgery
  • Infectious Diseases

Background:

  • Traumatic injuries to the head and face can lead to cerebrospinal fluid (CSF) leakage.
  • Recurrent bacterial meningitis is a serious complication associated with untreated CSF fistulas.

Observation:

  • Two pediatric cases of recurrent bacterial meningitis following traumatic CSF rhinorrhea are presented.
  • Case 1 involved a 1-year-old girl with a nasal injury and subsequent meningitis, treated with surgical repair.
  • Case 2 involved a 5-year-old girl with recurrent meningitis after head trauma, diagnosed via 3-D CT and surgically treated.

Findings:

  • Cerebrospinal fluid rhinorrhea, a leak of CSF from the nose, was diagnosed in both patients.
  • Surgical intervention successfully repaired the bone defects causing the CSF leaks.
  • Three-dimensional computed tomography (3-D CT) proved effective in identifying the CSF fistula.

Implications:

  • Prompt diagnosis and surgical management of traumatic CSF leaks are essential to prevent recurrent meningitis.
  • 3-D CT imaging is a valuable tool for detecting and localizing CSF fistulas.
  • Early intervention can significantly reduce the morbidity associated with bacterial meningitis in pediatric patients.

More Related Videos

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation06:59

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation

Published on: February 29, 2020

Related Concept Videos

Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...